Chong Chen, PhD
Professor, National Key Laboratory of Biotherapy, West China Hospital, Sichuan University.

Education

  • BS, Peking University (1999)
  • PhD, University of Michigan-Ann Arbor (2009)

Working Experience

  • Postdoc, Scott Lowe laboratory, Cold Spring Harbor Laboratory & Memorial Sloan Kettering Cancer Center (2010-2014)
  • Professor, Sichuan University (2014-)

Selective Publication

  • Wang M#, Chen X#, Tan P#, Wang Y#, Pan X, Lin T, Jiang Y, Wang B, Xu H, Wang Y, Yang Y, Wang J, Zhao L, Zhang J, Zhong A, Peng Y, Du J, Zhang Q, Zheng J, Chen J, Dai S, Na F, Lu Z, Liu J, Zheng X, Yang L, Zhang P, Han P, Gong Q, Zhong Q, Xiao K, Yang H, Deng H, Zhao Y, Shi H, Man J, Gou M, Zhao C, Dai L, Xue Z, Chen L, Wang Y, Zeng M, Huang C, Wei Q*, Wei Y, Liu Y*, Chen C*. Acquired semi-squamatization during chemotherapy suggests differentiation as a therapeutic strategy for bladder cancer. Cancer Cell. 2022 Sep 12;40(9):1044-1059.e8.

  • Na F, Pan X, Chen J, Chen X, Wang M, Chi P, You L, Zhang L, Zhong A, Zhao L, Dai S, Zhang M, Wang Y, Wang B, Zheng J, Wang Y, Xu J, Wang J, Wu B, Chen M, Liu H, Xue J, Huang M, Gong Y, Zhu J, Zhou L, Zhang Y, Yu M, Tian P, Fan M, Lu Z, Xue Z, Zhao Y, Yang H, Zhao C, Wang Y, Han J, Yang S, Xie D, Chen L, Zhong Q, Zeng M, Scott W. Lowe, Lu Y, Liu Y, Wei Y, Chen C. KMT2C deficiency promotes small cell lung cancer metastasis through DNMT3A-mediated epigenetic reprogramming. Nat Cancer (2022).

  • Pan X, Wang J, Guo L, Na F, Du J, Chen X, Zhong A, Zhao L, Zhang L, Zhang M, Wan X, Wang M, Liu H, Dai S, Tan P, Chen J, Liu Y, Hu B, Chen C. Identifying a confused cell identity for esophageal squamous cell carcinoma. Signal Transduct Target Ther. 2022 Apr 13;7(1):122. doi: 10.1038/s41392-022-00946-8.

  • Zhang Q, Zhao L, Yang Y, Li S, Liu Y, Chen C. Mosaic loss of chromosome Y promotes leukemogenesis and clonal hematopoiesis. JCI Insight. 2022 Feb 8;7(3):e153768. doi: 10.1172/jci.insight.153768.

  • Tan P, Wang M, Zhong A, Wang Y, Du J, Wang J, Qi L, Bi Z, Zhang P, Lin T, Zhang J, Yang L, Chen J, Han P, Gong Q, Liu Y, Chen C, Wei Q. SRT1720 inhibits the growth of bladder cancer in organoids and murine models through the SIRT1-HIF axis. Oncogene. 2021 Oct;40(42):6081-6092. doi: 10.1038/s41388-021-01999-9.

  • Chen M, Chen X, Li S, Pan X, Gong Y, Zheng J, Xu J, Zhao C, Zhang Q, Zhang S, Qi L, Wang Z, Shi K, Ding BS, Xue Z, Chen L, Yang S, Wang Y, Niu T, Dai L, Lowe SW, Chen C, Liu Y. An Epigenetic Mechanism Underlying Chromosome 17p Deletion-Driven Tumorigenesis. Cancer Discov. 2021 Jan;11(1):194-207. doi: 10.1158/2159-8290.CD-20-0336.

  • Chen J, Zhao L, Peng H, Dai S, Quan Y, Wang M, Wang J, Bi Z, Zheng Y, Zhou S, Liu Y, Chen C, Na F. An organoid-based drug screening identified a menin-MLL i nhibitor for endometrial cancer through regulating the HIF pathway. Cancer Gene Ther. 2020 Jul 7. doi: 10.1038/s41417-020-0190-y.

  • Wu B, Pan X, Chen X, Chen M, Shi K, Xu J, Zheng J, Niu T, Chen C, Shuai X, Liu Y. Epigenetic drug library screening identified an LSD1 inhibitor to target UTX-deficient cells for differentiation therapy. Signal Transduct Target Ther. 2019 Apr 26;4(1):11. doi: 10.1038/s41392-019-0040-2.

  • Liu Y, Chen C, Xu Z, Scuoppo C, Rillahan CD, Gao J, Spitzer B, Bosbach B, Kastenhuber ER, Baslan T, Ackermann S, Cheng L, Wang Q, Niu T, Schultz N, Levine RL, Mills AA, Lowe SW. Deletions linked to TP53 loss drive cancer through p53-independent mechanisms. Nature. 2016 Mar 24;531(7595):471-475. doi: 10.1038/nature17157.

  • Chen C, Liu Y, Rappaport AR, Kitzing T, Schultz N, Zhao Z, Shroff AS, Dickins RA, Vakoc CR, Bradner JE, Stock W, LeBeau MM, Shannon KM, Kogan S, Zuber J, Lowe SW. MLL3 functions as a chromosome 7q tumor suppressor in acute myeloid leukemia. Cancer Cell 2014 May 12; 25(5): 652-665.

  • Chen C, Liu Y, Lu C, Cross JR, Morris JP 4th, Shroff AS, Ward PS, Bradner JE, Thompson C, Lowe SW. Cancer-associated IDH2 mutants drive an acute myeloid leukemia that is susceptible to Brd4 inhibition. Genes Dev. 2013 Sep 15;27(18):1974-85.

  • Chen C, Liu Y, Liu Y*, Zheng P*. Mammalian target of rapamycin activation underlies HSC defects in autoimmune disease and inflammation in mice. Journal of Clinical Investigation 2010 Nov 1;120(11):4091-101.

  • Chen C, Liu Y, Liu R, Ikenoue T, Guan KL, Liu Y*, Zheng P*. TSC-mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species. J Exp Med. 2008 Sep 29;205(10):2397-408.

  • Chen C, Liu Y, Liu Y*, Zheng P*. 2009. mTOR Regulation and Therapeutic Rejuvenation of Aging Hematopoietic Stem Cells. Science Signaling 2009 Nov 24;2(98): ra75.