Yu Liu, PhD
Professor, National Key Laboratory of Biotherapy, West China Hospital, Sichuan University.

Education

  • BS, Beijing Normal University (1997)
  • MS, Beijing Normal University (2000)
  • PhD, Albert Einstein College of Medicine, Bronx (2008)

Working Experience

  • Postdoc, University of Michigan (2008-2010)
  • Postdoc, Cold Spring Harbor Laboratory & Memorial Sloan Kettering Cancer Center (2010-2015)
  • Professor, Sichuan University (2015-)

Selective Publication

  • Wang M#, Chen X#, Tan P#, Wang Y#, Pan X, Lin T, Jiang Y, Wang B, Xu H, Wang Y, Yang Y, Wang J, Zhao L, Zhang J, Zhong A, Peng Y, Du J, Zhang Q, Zheng J, Chen J, Dai S, Na F, Lu Z, Liu J, Zheng X, Yang L, Zhang P, Han P, Gong Q, Zhong Q, Xiao K, Yang H, Deng H, Zhao Y, Shi H, Man J, Gou M, Zhao C, Dai L, Xue Z, Chen L, Wang Y, Zeng M, Huang C, Wei Q*, Wei Y, Liu Y*, Chen C*. Acquired semi-squamatization during chemotherapy suggests differentiation as a therapeutic strategy for bladder cancer. Cancer Cell. 2022 Sep 12;40(9):1044-1059.e8.

  • Chen M*, Chen X*, Li S, Pan X, Gong Y, Zheng J, Xu J, Zhao C, Zhang Q, Zhang S, Qi L, Wang Z, Shi K, Ding BS, Xue Z, Chen L, Yang S, Wang Y, Niu T, Dai L, Lowe SW, Chen C#, Liu Yu#. An Epigenetic Mechanism Underlying Chromosome 17p Deletion-Driven Tumorigenesis. Cancer Discov. 2021 Jan;11(1):194-207. doi: 10.1158/2159-8290.CD-20-0336.

  • Liu Yu*, Chen C*, Xu Z, Scuoppo C, Rillahan CD, Gao J, Spitzer B, Bosbach B, Kastenhuber ER, Baslan T, Ackermann S, Cheng L, Wang Q, Niu T, Schultz N, Levine RL, Mills AA, Lowe SW. Deletions linked to TP53 loss drive cancer through p53-independent mechanisms. Nature. 2016 Mar 24;531(7595):471-475. doi: 10.1038/nature17157.

  • Liu P*, Pan X*, Chen C, Niu T, Shuai X, Wang J, Chen X, Liu J, Guo Y, Xie L, Wu Y, Liu Yu#, Liu T#. Nivolumab treatment of relapsed/refractory Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis in adults. Blood. 2020 Mar 12;135(11):826-833. doi: 10.1182/blood.2019003886.

  • Wu B, Pan X, Chen X, Chen M, Shi K, Xu J, Zheng J, Niu T, Chen C#, Shuai X#, Liu Yu#. Epigenetic drug library screening identified an LSD1 inhibitor to target UTX-deficient cells for differentiation therapy. Signal Transduct Target Ther. 2019 Apr 26;4:11. doi: 10.1038/s41392-019-0040-2.

  • Pan X, Wang J, Guo L, Na F, Du J, Chen X, Zhong A, Zhao L, Zhang L, Zhang M, Wan X, Wang M, Liu H, Dai S, Tan P, Chen J, Liu Yu#, Hu B#, Chen C#. Identifying a confused cell identity for esophageal squamous cell carcinoma. Signal Transduct Target Ther. 2022 Apr 13;7(1):122. doi: 10.1038/s41392-022-00946-8.

  • Ye P*, Liu Yu*, Chen C, Tang F, Wu Q, Wang X, Liu CG, Liu X, Liu R, Liu Y, Zheng P. An mTORC1-Mdm2-Drosha axis for miRNA biogenesis in response to glucose- and amino acid-deprivation. Mol Cell. 2015 Feb 19;57(4):708-720. doi: 10.1016/j.molcel.2014.12.034.

  • Chen C, Liu Yu, Rappaport AR, Kitzing T, Schultz N, Zhao Z, Shroff AS, Dickins RA, Vakoc CR, Bradner JE, Stock W, LeBeau MM, Shannon KM, Kogan S, Zuber J, Lowe SW. MLL3 is a haploinsufficient 7q tumor suppressor in acute myeloid leukemia. Cancer Cell. 2014 May 12;25(5):652-65. doi: 10.1016/j.ccr.2014.03.016.

  • Chen C, Liu Yu, Lu C, Cross JR, Morris JP 4th, Shroff AS, Ward PS, Bradner JE, Thompson C, Lowe SW. Cancer-associated IDH2 mutants drive an acute myeloid leukemia that is susceptible to Brd4 inhibition. Genes Dev. 2013 Sep 15;27(18):1974-85. doi: 10.1101/gad.226613.113.

  • Wu Q, Liu Yu, Chen C, Ikenoue T, Qiao Y, Li CS, Li W, Guan KL, Liu Y, Zheng P. The tuberous sclerosis complex-mammalian target of rapamycin pathway maintains the quiescence and survival of naive T cells. J Immunol. 2011 Aug 1;187(3):1106-12. doi: 10.4049/jimmunol.1003968.

  • Chen C, Liu Yu, Liu Y, Zheng P. Mammalian target of rapamycin activation underlies HSC defects in autoimmune disease and inflammation in mice. J Clin Invest. 2010 Nov;120(11):4091-101. doi: 10.1172/JCI43873.

  • Chen C, Liu Yu, Liu Y, Zheng P. mTOR regulation and therapeutic rejuvenation of aging hematopoietic stem cells. Sci Signal. 2009 Nov 24;2(98):ra75. doi: 10.1126/scisignal.2000559.