Our People

Meet Our Team

Principal Investigators

Chong Chen

Yu Liu

Postdoctoral Fellow

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Hongyu Liu

Baohong Wu

Wang Jian

Kan Wu

Manli Wang

Xudong Wan

Yiyun Wang

Zhongwang Wang

Ailing Zhong

Jianan Zheng

Qi Zhang

Xiaoqian Zhai

Hongyu Liu

Education:

BS, Chongqing Normal University PHD, Sichuan University Postdoc, Sichuan University

Research Interest:

Uncovering key molecular features and potential therapeutic targets in cancer development and treatment.

Publications:

Dissecting the genetic and microenvironmental factors of gastric tumorigenesis in mice. Cell Reports.2022.

Baohong Wu

Education:

B.S. ChongQing University of Arts and Science M.S. Sichuan University Ph.D. Sichuan University

Research Interest:

1) The role and mechanisms of alternative splicing underlying stepwise leukemogenesis 2) Characterizing the tipping point of malignant transformation along the tumor progression trajectory 3) Elucidating the mechanisms of cell-cell interactions in tumor immune evasion

Publications:

1). Wu B#, Chen X#, Pan X# et al. Single-cell transcriptome analyses reveal critical roles of RNA splicing during leukemia progression. PLOS Biology. 2023 2). Hang XH#, Zhao L#, Wu B# et al.BCL-2 isoform β promotes angiogenesis by TRiC-mediated upregulation of VEGF-A in lymphoma. Oncogene. 2022、 3). Wu B et al. Epigenetic drug library screening identified an LSD1 inhibitor to target UTX-deficient cells for differentiation therapy. Signal Transduction and Targeted Therapy. 2019

Fundings:

1). the National Natural Science Foundation of China 2). the Natural Science Foundation of Sichuan Province of China 3). the China Postdoctoral Science Foundation 4). the China Postdoctoral Science Foundation 5). the Post-Doctor Research Project of Sichuan University

Reward:

1). National scholarship (2018) 2). Outstanding PhD graduates of Sichuan University (2022)

Wang Jian

Education:

B.S. Chengdu University of Technology M.S. Sichuan University Ph.D. West China Hospital, Sichuan University

Research Interest:

Esophageal carcinoma primary orthotopic animal model; Spatial molecular pathology; Spatial transcriptome sequencing.

Publications:

1. A platform of functional studies of ESCCassociated gene mutations identifies the roles of TGFBR2 in ESCC progression and metastasis, Cell Reports, 2024, 43(11) 2. Identifying a confused cell identity for esophageal squamous cell carcinoma, Signal Transduction and Targeted Therapy, 2022, 7(5): 1692-1702 3. Primary and Orthotopic Murine Models of Nasopharyngeal Carcinoma Reveal Molecular Mechanisms Underlying its Malignant Progression, Advanced Science, 2024, Adv. Sci. 2024(2403161)

Kan Wu

Education:

Bachelor of Medicine: Lanzhou University (Clinical Medicine) M.M & M.D: Sichuan University (Surgery, Urology)

Research Interest:

Basic and clinical studies in urological tumors, focusing on molecular mechanisms, therapeutic strategies, and clinical outcomes.

Publications:

1. Wang M*, Chen X*, Tan P*，et al., Acquired semi-squamatization during chemo treatment suggests a differentiation therapy for bladder cancer. Cancer Cell, 2022 2. Discovery of a glucocorticoid receptor (GR) activity signature correlates with immune cell infiltration in adrenocortical carcinoma. Journal for ImmunoTherapy of Cancer. 2023. 2. Clinicopathologic characteristics and outcomes of prostate cancer incidentally discovered at the time of radical cystoprostatectomy: a population-based cohort study. Int J Surg. 3. Benefit of Postoperative Radiotherapy for Patients With Nonmetastatic Adrenocortical Carcinoma: A Population-Based Analysis. Journal of the National Comprehensive Cancer Network.

Fundings:

1. National Natural Science Foundation of China 2. National-funded Postdoctoral Researcher Program (Category C) 3. Sichuan Provincial Natural Science Foundation 3. China Postdoctoral Science Foundation 5. Postdoctor Research Fund of West China Hospital, Sichuan University

Manli Wang

Education:

BS, Southwest jiaotong University PhD, Sichuan University

Research Interest:

1. Precise cancer mouse model establishment: use organoid culture and gene editing techniques to construct primary, orthotopic mouse tumor models. 2. Based on tumor organoid and mouse models, explore the molecular mechanisms of tumor initiation, development, metastasis, and drug resistance, and develop therapeutic targets and drugs.

Publications:

1. Wang M*, Chen X*, Tan P*，et al., Acquired semi-squamatization during chemo treatment suggests a differentiation therapy for bladder cancer. Cancer Cell, 2022 2. TAN P*, Wang M*, ZHONG A, et al. SRT1720 inhibits the growth of bladder cancer in organoids and murine models through the SIRT1-HIF axis. Oncogene, 2021 3. Zhai X*, Wang M*, Zhang Q*, Li D*, et al. Identifying the intergenic ALK fusion LOC388942-ALK as a driver of non-small cell lung cancer. MedComm, 2025. 4. Na F*, Pan X*, Chen J*, Chen X*, Wang M, et al., A Coherent Histone and DNA Hypomethylation Reprogramming Drives Small Cell Lung Cancer Metastasis. Nature Cancer, 2022 5. Wang X, Zhou R, Xiong Y, Zhou L, Yan X, Wang M, et al. Sequential fate-switches in stem-like cells drive the tumorigenic trajectory from human neural stem cells to malignant glioma. Cell Research, 2021. 6. Lu Z, Zhong A, Liu H, Zhang M, Chen X, Pan X, Wang M, et al. Dissecting the genetic and microenvironmental factors of gastric tumorigenesis in mice. Cell Reports. 2022. 7. Pan X, Wang J, Guo L, Na F, Du J, Chen X, Zhong A, Zhao L, Zhang L, Zhang M, Wan X, Wang M, et al. Identifying a confused cell identity for esophageal squamous cell carcinoma. Signal Transduct Target Ther.

Fundings:

1. National Natural Science Foundation of China 2. Sichuan Science and Technology Program 3. Post-Doctor Research Project, West China Hospital, Sichuan University 4. Sichuan University Postdoctoral Interdisciplinary Innovation Fund

Reward:

1.First Prize of the 2023 Sichuan-Chongqing Science and Technology Academic Conference, December 2023 2.Second Prize for Youth Innovation at the Bangchui Island Tumor Forum, March 2023, 3. Outstanding Doctoral Graduate of Sichuan University, June 2022

Xudong Wan

Education:

BS, Guangxi University PhD, Sichuan University

Research Interest:

Yiyun Wang

Education:

2015-2019: Bachelor's degree, Beijing University of Chemical Technology 2019-present: PhD student, Sichuan University

Research Interest:

Investigating the mechanisms underlying the malignant progression of small-cell lung cancer

Publications:

Acquired semi-squamatization during chemotherapy suggests differentiation as a therapeutic strategy for bladder cancer. Cancer Cell. 2022 (co-first)

Reward:

National Doctoral Innovation Scholarship WESTVAC Innovation Scholarship

Zhongwang Wang

Education:

MBBS, Southeast University MMSc, Sichuan University MD, Sichuan University

Research Interest:

Investigating the pathogenesis and novel therapeutic strategies for hematologic malignancies.

Publications:

DNMT3AR882H accelerates angioimmunoblastic T-cell lymphoma in mice. oncogene.2023

Ailing Zhong

Education:

BS: Southwest University Ph.D. Sichuan University

Research Interest:

• The epigenetic reprogramming mechanisms in tumorigenesis and maintenance. • The innate and acquired resistance mechanism of immunotherapy. • The molecular mechanism of tumor metastasis.

Publications:

1. Wang Y*, Zhong A*, Wang B*, Zhai X, Lei C, Liang Z, Zhong J, et al. Blood-brain barrier-like vasculature structures prevent T cell infiltration in neuroendocrine tumors. Under review at Cell and Cancer Cell (Cell Press parallel submission). 2. Zhang M*, Zhong A*, Liu H*, Zhao L*, Wang Y, et al. EZH2 loss promotes gastric squamous cell carcinoma. Nature Communications, accepted for publication. 3. Liu H*, Zhong A*, Lu Z*, Zhang M, Wang Y, et al. Dual roles of ARID1A in both mucin production and secretion to restrain gastric signet ring cell carcinoma. Manuscript in revision for Nature Communications. 4. Xu J*, Zhong A*, Zhang S*, Chen M, Zhang L, Hang X, et al. KMT2D Deficiency Promotes Myeloid Leukemias which Is Vulnerable to Ribosome Biogenesis Inhibition. Adv Sci. 2023 Jul;10(19): e2206098. 5. Lu Z*, Zhong A*, Liu H*, Zhang M*, Chen X, Pan X, et al. Dissecting the genetic and microenvironmental factors of gastric tumorigenesis in mice. Cell Rep. 2022 Oct 18;41(3):111482. 6. Pan X, Wang J, Guo L, Na F, Du J, Chen X, Zhong A, Zhao L, Zhang L, Zhang M, Wan X, Wang M, et al. Identifying a confused cell identity for esophageal squamous cell carcinoma. Signal Transduct Target Ther. 2023.

Reward:

2022-2023 Innovation Scholarship of Ph.D. Student, Sichuan University 2021-2023 First-class Scholarship of Ph.D. Student, Sichuan University 2020-2021 Sino Biological Scholarship, Sino Biological Inc. 2020-2021 Spark light Inspiration Scholarship 2019-2023 Outstanding Graduate Student, Sichuan University

Jianan Zheng

Education:

BS, Sichuan University PhD, Sichuan University

Research Interest:

Investigating the molecular mechanisms underlying chromosomal variation in AML and developing therapeutic strategies.

Publications:

DNMT3A R882H Accelerates Angioimmunoblastic T-cell Lymphoma in Mice. Oncogene. 2023.

Reward:

Sichuan University First-Class Scholarship

Qi Zhang

Education:

BS, Southwest Jiaotong University MS/PhD, National Key Laboratory of Biotherapy, Sichuan University Assistant Researcher/Postdoctoral Fellow (2022.7–present), supervised by Prof. Liu Yu

Research Interest:

Investigating the functional roles of chromosomal abnormalities in the pathogenesis and progression of leukemia.

Publications:

First-author publications: Blood, JCI Insight Co-authored publications: Cancer Discovery, Cancer Cell, Cell Reports

Fundings:

- National Natural Science Foundation of China - China Postdoctoral Science Foundation

Reward:

National Funded Postdoctoral Researcher Program (Grade B, 2023)

Xiaoqian Zhai

Education:

BS, Shaanxi University of Chinese Medicine MD, Sichuan university PhD, Sichuan University

Research Interest:

Zhai focuses on resistance to immunotherapy and targeted therapies in lung cancer

Publications:

• Identified and demonstrated the oncogenic potential of the intergenic fusion LOC388942-ALK in lung cancer, suggesting that FOS inhibitors may offer therapeutic benefits for such cases. • Medcomm, 2025. J Hematol Oncol, 2025.

PhD Student

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Siqi Dai

Xintong Deng

Hanyu Jiang

Ruobing Li

Xiangmeng Luo

Yiman Peng

Yucui Shang

Bo Wang

Yuanjun Wu

Yuying Wang

Yang Yang

Yucen Yang

Jiabo Zhang

Lanxin Zhang

Shiyu Zhang

Siqi Dai

Education:

BS, Sichuan Agricultural University

Research Interest:

Precision treatment of endometrial cancer Exploration of Chemotherapy Resistance Mechanism in Small Cell Lung Cancer

Publications:

A New Type of Endometrial Cancer Models in Mice Revealing the Functional Roles of Genetic Drivers and Exploring their Susceptibilities.Advanced Science.2023

Xintong Deng

Education:

BS, Sichuan University.

Research Interest:

Molecular pathogenesis of hematologic malignancies.

Hanyu Jiang

Education:

BS. Hunan Normal University

Research Interest:

Molecular pathogenesis of hematologic malignancies.

Ruobing Li

Education:

BS, Sichuan University，Pharmacy.

Research Interest:

Elucidating the molecular mechanisms of development and progression of chromosomal copy number variation (CNV; deletions/amplifications) in hematologic malignancies.

Reward:

National Doctoral Innovation Scholarship

Xiangmeng Luo

Education:

BS, Sichuan University.

Research Interest:

Bioinformatics; lung cancer metastasis SCLC radioresistance NSCLC/ESCC immunotherapy resistance cancer epigenetic regulation.

Publications:

A platform of functional studies of ESCC-associated gene mutations reveals the roles of TGFBR2 in ESCC progression and metastasis

Reward:

2023-2024, WESTVAC Innovation Scholarship

Yiman Peng

Education:

BS, Southwest Jiaotong University.

Research Interest:

Using bioinformatics analysis to uncover key molecular features and potential therapeutic targets in cancer development and treatment.

Publications:

Primary and Orthotopic Murine Models of Nasopharyngeal Carcinoma Reveal Molecular Mechanisms Underlying its Malignant Progression. Advanced Science. 2024.

Reward:

National scholarship 2023-2024, WESTVAC Innovation Scholarship

Yucui Shang

Education:

BS, LanZhou University

Research Interest:

Utilizing bioinformatics approaches to investigate the molecular mechanisms, genomic alterations, and therapeutic strategies in lung cancer and leukemia.

Bo Wang

Education:

BS, Southwestern university

Research Interest:

Focused on investigating the molecular mechanisms underlying resistance to immunotherapy and radiotherapy in lung cancer, with the aim of identifying predictive biomarkers and potential therapeutic targets for combination therapy.

Yuanjun Wu

Education:

BS, Xi'an Jiaotong University

Research Interest:

Lung cancer radiotherapy and immunotherapy.

Reward:

Abbott Nutrition Scholarship (2023)

Yuying Wang

Education:

BS, China Pharmaceutical University MS, Sichuan University

Research Interest:

Intrapulmonary metastasis of lung cancer immune therapy resistance in non-small cell lung cancer

Publications:

Acquired resistance to immunotherapy by physical barriers with cancer cell–expressing collagens in non–small cell lung cancer. PNS. 2025.

Reward:

First-Class Scholarship of Sichuan University

Yang Yang

Education:

BS, Lanzhou University MS, West China hospital of Sichuan University

Research Interest:

Digestive cancer

Publications:

Protein tyrosine kinase inhibitor resistance in malignant tumors: molecular mechanisms and future perspective. Signal Transduct Target Ther. (2022)

Reward:

National scholarship.

Yucen Yang

Education:

BS, Sichuan Agricultural University

Research Interest:

Tumor cell lineage plasticity, drug resistance and therapeutic target

Jiabo Zhang

Education:

BS, Sichuan Agricultural University

Research Interest:

Mainly studying the mechanisms related to acquired drug resistance and metastasis of non-small cell lung cancer and bladder cancer.

Reward:

National scholarship. Second-class Scholarship

Lanxin Zhang

Education:

BS, Sichuan Agricultural University

Research Interest:

Research on the Tumorigenesis Mechanism of Hematological Tumors

Reward:

Chen Yuxin First-Class Scholarship for Outstanding Students

Shiyu Zhang

Education:

West China School of Medicine, Sichuan University, Clinical Medicine (Five-year program), Bachelor of medicine

Research Interest:

Urological cancer preclinical models (PDX, organoids and primary, orthotopic, driver-defined mouse models); The role of epigenetic reprogramming in urothelial tumours initiation and progression; novel therapeutic targets discovery, identification and translational validation.

Master Student

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Chunyan Chen

Guixin Cheng

HuiHui Hu

Chang Lei

Donglin Li

Huiling Luo

Jiaxin Li

Yanxin Li

Yanmou Wu

Shuhao Zhou

Wanyue Zhou

Chunyan Chen

Education:

BS, Capital Normal University

Research Interest:

Guixin Cheng

Education:

BS, Sichuan Agriculature university

Research Interest:

Exploration of the Pathogenesis and Drug Treatment Mechanisms of Lymphoma

Publications:

Optimization of ultrasound-assisted enzymatic extraction, chemical constituents, biological activities, and stability of Camellia oleifera fruit shell brown pigments. LWT-Food Science and Technology. 2024

HuiHui Hu

Education:

BS, Sichuan University

Research Interest:

Using the Amplication-Editing technology to perform large-scale chromosomal editing，results in the formation of megabase (Mb)-level chromosomal amplifications.

Chang Lei

Education:

BS, Beijing University of Chinese Medicine

Research Interest:

ecDNA and metastasis of lung cancer

Donglin Li

Education:

BS, Sichuan University

Research Interest:

Bioinformation

Publications:

Identifying the Intergenic ALK Fusion LOC388942-ALK as a Driver of Non-Small Cell Lung Cancer. MedComm. 2025.

Huiling Luo

Education:

BS, SiChuan Agricultural University

Research Interest:

Using gene editing technology to perform large-scale deletion of chromosomal fragments, and investigating the synergistic effect of deletion gene groups in tumorigenesis.

Jiaxin Li

Education:

BS, SiChuan Agricultural University

Research Interest:

Stomach cancer lung cancer

Yanxin Li

Education:

BS, Yanbian University

Research Interest:

The Molecular Mechanisms of Hematologic Malignancy Onset and Progression, and Targeted Therapy.

Reward:

Sichuan University Graduate Scholarship

Yanmou Wu

Education:

BS, Sichuan University (undergraduate)

Research Interest:

lung cancer tumorigenesis the mechanism of lung cancer chemoresistant and metastasis and exploring potential therapy

Publications:

Identifying the Intergenic ALK Fusion LOC388942-ALK as a Driver of Non–Small Cell Lung Cancer，Medcomm，2025（Accepted） New Era in the Treatment of SCLC: Comprehensive Analysis from Drug Resistance to the Clinic，Journal of Hematology & Oncology

Reward:

Sichuan University Comprehensive Third Prize Scholarship

Shuhao Zhou

Education:

BS, Sichuan university

Research Interest:

bioinformation work in tumor and other disease.

Wanyue Zhou

Education:

BS, Sichuan University

Research Interest:

Using gene editing technology to perform large-scale amplification of chromosomal fragments, and investigating the impact of cellular large fragment amplification on tumorigenesis and development.

Laboratory Assistants

Ziling Dong

Pengli Chen

Ziling Dong

Education:

Jobs:

Research Assistant

Pengli Chen

Education:

MS, Zhengzhou University

Jobs:

Genetic Mouse Breeding and Financial Reimbursement.

Alumni

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Xiaofeng Deng

Mengsha Zhang

Mei Chen

Pengliang Chi

Linjie Guo

Xiaohang Hang

Xi Huang

Dan Liao

Shujun Li

Chao Liu

Li Liu

Lin Luo

Zhenghao Lu

Lei Lv

Feifei Na

Kaidou Shi

Zhengmin Xu

Yi Yang

Lei Zhao

Jingyao Chen

Xuelan Chen

Pengpeng Liu

Ping Tan

Xiangyu Pan

Lu Qi

Lu Zhang

Yingjie Wang

Jing Xu

Jiajia Du

Xiaofeng Deng

Education:

BS, Nanjing Medical University

Research Interest:

Research on the Mechanism of Immune Therapy Resistance and Epigenetic Genes in Lung Squamous Cell Carcinoma

Mengsha Zhang

Education:

B.S., Sichuan Agricultural University M.S., Sichuan University Ph.D., Sichuan University

Research Interest:

Mechanisms and Potential Therapeutic Targets in Gastric Cancer

Publications:

EZH2 loss promotes gastric squamous cell carcinoma. Nature communications, 2025. Dissecting the genetic and microenvironmental factors of gastric tumorigenesis in mice. Cell reports.2022. Epigenetic reprogramming in gastrointestinal cancer: biology and translational perspectives. MedComm.2024 \

Reward:

WESTVAC Innovation Scholarship Outstanding Graduate of Sichuan University Outstanding Postgraduate of Sichuan University

Mei Chen

Education:

PhD

Pengliang Chi

Education:

Master

Linjie Guo

Education:

Postdoc

Xiaohang Hang

Education:

PhD

Xi Huang

Education:

PhD

Dan Liao

Education:

Master

Shujun Li

Education:

PhD

Chao Liu

Education:

Master

Li Liu

Education:

Postdoc

Lin Luo

Education:

Master

Zhenghao Lu

Education:

Postdoc

Lei Lv

Education:

Postdoc

Feifei Na

Education:

Postdoc

Kaidou Shi

Education:

Master

Zhengmin Xu

Education:

PhD

Yi Yang

Education:

PhD

Lei Zhao

Education:

Master

Jingyao Chen

Education:

Postdoc

Xuelan Chen

Education:

Postdoc

Pengpeng Liu

Education:

Postdoc

Ping Tan

Education:

Postdoc

Xiangyu Pan

Education:

PhD

Lu Qi

Education:

PhD

Lu Zhang

Education:

Master

Yingjie Wang

Education:

PhD

Jing Xu

Education:

PhD

Jiajia Du

Education:

Master