#Co-first authors; *Co-corresponding authors
2024
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Wang J#, Du J#, Luo X#, Guo L#, Liu Y#, Zhou J, Zou Y, Lu Z, Pan X, Chen X, Zhong A, Wan X, Wang L, Liu H, Dai S, Zhang S, Xiong X, Tan P, Wang M, Wu B, Zhang Q, Wang Y, Zhang M, Lu R, Lin H, Li Y, Li Y, Han Z, Chen L*, Hu B*, Liu Y*, Na F*, Chen C*. A platform of functional studies of ESCC-associated gene mutations identifies the roles of TGFBR2 in ESCC progression and metastasis. Cell Rep. 2024 Nov 26;43(11):114952. doi: 10.1016/j.celrep.2024.114952
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Wan X#, Liu Y#, Peng Y#, Wang J#, Yan SM#, Zhang L, Wu W, Zhao L, Chen X, Ren K, Long H, Luo Y, Yan Q, Zhang L, Lei D, Liu P, Li S, Liu L, Guo L, Du J, Zhang M, Dai S, Yang Y, Liu H, Chen N, Bei J, Feng L, Liu Y*, Zeng MS*, Chen C*, Zhong Q*. Primary and Orthotopic Murine Models of Nasopharyngeal Carcinoma Reveal Molecular Mechanisms Underlying its Malignant Progression. Adv Sci (Weinh). 2024 Jul 25:e2403161.
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2023
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Zhang Q#, Li H#, Chen X#, Gu F, Zhang L, Zhang L, Chen T, Chen Q, Meng W, Wu Y, Chang H, Liu T, Chen C, Ma H*, Liu Y*. Identifying STRN3-RARA as a new fusion gene for acute promyelocytic leukemia. Blood. 2023 Oct 26;142(17):1494-1499.
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Chen J#, Dai S#, Zhao L#, Peng Y, Sun C, Peng H, Zhong Q, Quan Y, Li Y, Chen X, Pan X, Zhong A, Wang M, Zhang M, Yang S, Lu Y, Lian Z, Liu Y, Zhou S, Li Z, Na F*, Chen C*. A New Type of Endometrial Cancer Models in Mice Revealing the Functional Roles of Genetic Drivers and Exploring their Susceptibilities. Adv Sci (Weinh). 2023 Jun 20:e2300383.
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Xu J#, Zhong A#, Zhang S#, Chen M, Zhang L, Hang X, Zheng J, Wu B, Deng X, Pan X, Wang Z, Qi L, Shi K, Li S, Wang Y, Wang M, Chen X, Zhang Q, Liu P, Gale RP, Chen C, Liu Y*, Niu T*. KMT2D Deficiency Promotes Myeloid Leukemias which Is Vulnerable to Ribosome Biogenesis Inhibition. Adv Sci (Weinh). 2023 May 4:e2206098.
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Wu B#, Chen X#, Pan X#, Deng X, Li S, Wang Z, Wang J, Liao D, Xu J, Chen M, Zhao C, Xue Z, Wang Y, Niu T, Lin J, Chen L*, Liu Y*, Chen C*. Single-cell transcriptome analyses reveal critical roles of RNA splicing during leukemia progression. PLoS Biol. 2023 May 2;21(5):e3002088.
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Zheng J#, Wang Z#, Pan X#, Zhang Z, Li H, Deng X, Liu P, Zhang Q, Na F, Chen C, Niu T*, Liu Y*. DNMT3AR882H accelerates angioimmunoblastic T-cell lymphoma in mice. Oncogene. 2023 May 1. [Link] [PDF]
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Qi L, Pan X, Chen X, Liu P, Chen M, Zhang Q, Hang X, Tang M, Wen D, Dai L, Chen C, Liu Y*, Xu Z*. COX-2/PGE2 upregulation contributes to the chromosome 17p-deleted lymphoma. Oncogenesis. 2023 Feb 7;12(1):5.
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2022
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Lu Z#, Zhong A#, Liu H#, Zhang M#, Chen X, Pan X, Wang M, Deng X, Gao L, Zhao L, Wang J, Yang Y, Zhang Q, Wu B, Zheng J, Wang Y, Song X, Liu K, Zhang W, Chen X, Yang K, Chen X, Zhao Y, Zhao C, Wang Y, Chen L, Zhou Z, Hu J*, Liu Y*, Chen C*. Dissecting the genetic and microenvironmental factors of gastric tumorigenesis in mice. Cell Rep. 2022 Oct 18;41(3):111482.
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Wang M#, Chen X#, Tan P#, Wang Y#, Pan X, Lin T, Jiang Y, Wang B, Xu H, Wang Y, Yang Y, Wang J, Zhao L, Zhang J, Zhong A, Peng Y, Du J, Zhang Q, Zheng J, Chen J, Dai S, Na F, Lu Z, Liu J, Zheng X, Yang L, Zhang P, Han P, Gong Q, Zhong Q, Xiao K, Yang H, Deng H, Zhao Y, Shi H, Man J, Gou M, Zhao C, Dai L, Xue Z, Chen L, Wang Y, Zeng M, Huang C, Wei Q*, Wei Y, Liu Y*, Chen C*. Acquired semi-squamatization during chemotherapy suggests differentiation as a therapeutic strategy for bladder cancer. Cancer Cell. 2022 Sep 12;40(9):1044-1059.e8.
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Hang X#, Zhao L#, Wu B#, Li S, Liu P, Xu J, Wang X, Chi P, Chen C, Niu T, Dai L*, Liu Y*. BCL-2 isoform β promotes angiogenesis by TRiC-mediated upregulation of VEGF-A in lymphoma. Oncogene. 2022 Jul;41(28):3655-3663.
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Na F#, Pan X#, Chen J#, Chen X#, Wang M, Chi P, You L, Zhang L, Zhong A, Zhao L, Dai S, Zhang M, Wang Y, Wang B, Zheng J, Wang Y, Xu J, Wang J, Wu B, Chen M, Liu H, Xue J, Huang M, Gong Y, Zhu J, Zhou L, Zhang Y, Yu M, Tian P, Fan M, Lu Z, Xue Z, Zhao Y, Yang H, Zhao C, Wang Y, Han J, Yang S, Xie D, Chen L, Zhong Q, Zeng M, Scott W. Lowe, Lu Y, Liu Y, Wei Y, Chen C. KMT2C deficiency promotes small cell lung cancer metastasis through DNMT3A-mediated epigenetic reprogramming. Nat Cancer (2022).
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Pan X#, Wang J#, Guo L#, Na F#, Du J, Chen X, Zhong A, Zhao L, Zhang L, Zhang M, Wan X, Wang M, Liu H, Dai S, Tan P, Chen J, Liu Y*, Hu B*, Chen C*. Identifying a confused cell identity for esophageal squamous cell carcinoma. Signal Transduct Target Ther. 2022 Apr 13;7(1):122.
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Hong W#, Yang J#, Zou J#, Bi Z#, He C#, Lei H#, He X, Li X, Alu A, Ren W, Wang Z, Jiang X, Zhong K, Jia G, Yang Y, Yu W, Huang Q, Yang M, Zhou Y, Zhao Y, Kuang D, Wang J, Wang H, Chen S, Luo M, Zhang Z, Lu T, Chen L, Que H, He Z, Sun Q, Wang W, Shen G, Lu G, Zhao Z, Yang L, Yang J, Wang Z, Li J, Song X, Dai L, Chen C, Geng J, Gou M, Chen L, Dong H, Peng Y, Huang C, Qian Z, Cheng W, Fan C, Wei Y, Su Z, Tong A, Lu S, Peng X, Wei X. Histones released by NETosis enhance the infectivity of SARS-CoV-2 by bridging the spike protein subunit 2 and sialic acid on host cells. Cell Mol Immunol. 2022 Mar 10:1–11.
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Zhao C, Lancman JJ, Yang Y, Gates KP, Cao D, Barske L, Matalonga J, Pan X, He J, Graves A, Huisken J, Chen C, Dong PDS. Intrahepatic cholangiocyte regeneration from an Fgf-dependent extrahepatic progenitor niche in a zebrafish model of Alagille Syndrome. Hepatology. 2022 Mar;75(3):567-583.
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Zhang Q, Zhao L, Yang Y, Li S, Liu Y, Chen C. Mosaic loss of chromosome Y promotes leukemogenesis and clonal hematopoiesis. JCI Insight. 2022 Feb 8;7(3):e153768.
[PubMed] [PDF]
2021
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Tan P#, Wang M#, Zhong A, Wang Y, Du J, Wang J, Qi L, Bi Z, Zhang P, Lin T, Zhang J, Yang L, Chen J, Han P, Gong Q, Liu Y, Chen C*, Wei Q*. SRT1720 inhibits the growth of bladder cancer in organoids and murine models through the SIRT1-HIF axis. Oncogene. 2021 Oct;40(42):6081-6092.
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Wang X, Zhou R, Xiong Y, Zhou L, Yan X, Wang M, Li F, Xie C, Zhang Y, Huang Z, Ding C, Shi K, Li W, Liu Y, Cao Z, Zhang ZN, Zhou S, Chen C, Zhang Y, Chen L, Wang Y. Sequential fate-switches in stem-like cells drive the tumorigenic trajectory from human neural stem cells to malignant glioma. Cell Res. 2021 Jun;31(6):684-702.
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Chen J, Zhao L, Peng H, Dai S, Quan Y, Wang M, Wang J, Bi Z, Zheng Y, Zhou S, Liu Y, Chen C*, Na F*. An organoid-based drug screening identified a menin-MLL inhibitor for endometrial cancer through regulating the HIF pathway. Cancer Gene Ther. 2021 Feb;28(1-2):112-125.
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Chen M#, Chen X#, Li S, Pan X, Gong Y, Zheng J, Xu J, Zhao C, Zhang Q, Zhang S, Qi L, Wang Z, Shi K, Ding BS, Xue Z, Chen L, Yang S, Wang Y, Niu T, Dai L, Lowe SW, Chen C*, Liu Y*. An Epigenetic Mechanism Underlying Chromosome 17p Deletion-Driven Tumorigenesis. Cancer Discov. 2021 Jan;11(1):194-207.
[PubMed] [PDF]
2020
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Yang J, Wang W, Chen Z, Lu S, Yang F, Bi Z, Bao L, Mo F, Li X, Huang Y, Hong W, Yang Y, Zhao Y, Ye F, Lin S, Deng W, Chen H, Lei H, Zhang Z, Luo M, Gao H, Zheng Y, Gong Y, Jiang X, Xu Y, Lv Q, Li D, Wang M, Li F, Wang S, Wang G, Yu P, Qu Y, Yang L, Deng H, Tong A, Li J, Wang Z, Yang J, Shen G, Zhao Z, Li Y, Luo J, Liu H, Yu W, Yang M, Xu J, Wang J, Li H, Wang H, Kuang D, Lin P, Hu Z, Guo W, Cheng W, He Y, Song X, Chen C, Xue Z, Yao S, Chen L, Ma X, Chen S, Gou M, Huang W, Wang Y, Fan C, Tian Z, Shi M, Wang FS, Dai L, Wu M, Li G, Wang G, Peng Y, Qian Z, Huang C, Lau JY, Yang Z, Wei Y, Cen X, Peng X, Qin C, Zhang K, Lu G, Wei X. A vaccine targeting the RBD of the S protein of SARS-CoV-2 induces protective immunity. Nature. 2020 Oct;586(7830):572-577.
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Lu Y#, Xue J#, Deng T, Zhou X, Yu K, Deng L, Huang M, Yi X, Liang M, Wang Y, Shen H, Tong R, Wang W, Li L, Song J, Li J, Su X, Ding Z, Gong Y, Zhu J, Wang Y, Zou B, Zhang Y, Li Y, Zhou L, Liu Y, Yu M, Wang Y, Zhang X, Yin L, Xia X, Zeng Y, Zhou Q, Ying B, Chen C, Wei Y, Li W, Mok T. Safety and feasibility of CRISPR-edited T cells in patients with refractory non-small-cell lung cancer. Nat Med. 2020 May;26(5):732-740.
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Liu P#, Pan X#, Chen C, Niu T, Shuai X, Wang J, Chen X, Liu J, Guo Y, Xie L, Wu Y, Liu Y*, Liu T*. Nivolumab treatment of relapsed/refractory Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis in adults. Blood. 2020 Mar 12;135(11):826-833.
[PubMed] [PDF]
2019
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Huang L, Li H, Li L, Niu L, Seupel R, Wu C, Cheng W, Chen C, Ding B, Brennan PE, Yang S. Discovery of Pyrrolo[3,2- d]pyrimidin-4-one Derivatives as a New Class of Potent and Cell-Active Inhibitors of P300/CBP-Associated Factor Bromodomain. J Med Chem. 2019 May 9;62(9):4526-4542.
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Wu B, Pan X, Chen X, Chen M, Shi K, Xu J, Zheng J, Niu T, Chen C*, Shuai X*, Liu Y*. Epigenetic drug library screening identified an LSD1 inhibitor to target UTX-deficient cells for differentiation therapy. Signal Transduct Target Ther. 2019 Apr 26;4:11.
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Xu J, Hang X, Wu B, Chen C, Liu Y*. Epigenetic Abnormalities in Acute Myeloid Leukemia and Leukemia Stem Cells. Adv Exp Med Biol. 2019;1143:173-189.
[PubMed]
2018
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Huang G, Yin L, Lan J, Tong R, Li M, Na F, Mo X, Chen C, Xue J, Lu Y. Synergy between peroxisome proliferator-activated receptor γ agonist and radiotherapy in cancer. Cancer Sci. 2018 Jul;109(7):2243-2255.
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Chen M, Yang Y, Liu Y, Chen C. The Role of Chromosome Deletions in Human Cancers. Adv Exp Med Biol. 2018;1044:135-148.
[PubMed] [PDF]
2017
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Cao Z, Ye T, Sun Y, Ji G, Shido K, Chen Y, Luo L, Na F, Li X, Huang Z, Ko JL, Mittal V, Qiao L, Chen C, Martinez FJ, Rafii S, Ding BS. Targeting the vascular and perivascular niches as a regenerative therapy for lung and liver fibrosis. Sci Transl Med. 2017 Aug 30;9(405):eaai8710.
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Sun QZ, Lin GF, Li LL, Jin XT, Huang LY, Zhang G, Yang W, Chen K, Xiang R, Chen C, Wei YQ, Lu GW, Yang SY. Discovery of Potent and Selective Inhibitors of Cdc2-Like Kinase 1 (CLK1) as a New Class of Autophagy Inducers. J Med Chem. 2017 Jul 27;60(14):6337-6352.
[PubMed] [PDF]
2016
- Liu Y#, Chen C#, Xu Z, Scuoppo C, Rillahan CD, Gao J, Spitzer B, Bosbach B, Kastenhuber ER, Baslan T, Ackermann S, Cheng L, Wang Q, Niu T, Schultz N, Levine RL, Mills AA, Lowe SW*. Deletions linked to TP53 loss drive cancer through p53-independent mechanisms. Nature. 2016 Mar 24;531(7595):471-475.
[PubMed] [PDF]
2015
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Yao S, He Z, Chen C. CRISPR/Cas9-Mediated Genome Editing of Epigenetic Factors for Cancer Therapy. Hum Gene Ther. 2015 Jul;26(7):463-71.
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Appelmann I, Rillahan CD, de Stanchina E, Carbonetti G, Chen C, Lowe SW, Sherr CJ. Janus kinase inhibition by ruxolitinib extends dasatinib- and dexamethasone-induced remissions in a mouse model of Ph+ ALL. Blood. 2015 Feb 26;125(9):1444-51.
[PubMed] [FullText] -
Chen C, Liu Y, Rappaport AR, Kitzing T, Schultz N, Zhao Z, Shroff AS, Dickins RA, Vakoc CR, Bradner JE, Stock W, LeBeau MM, Shannon KM, Kogan S, Zuber J, Lowe SW*. MLL3 is a haploinsufficient 7q tumor suppressor in acute myeloid leukemia. Cancer Cell. 2014 May 12;25(5):652-65. doi: 10.1016/j.ccr.2014.03.016. Epub 2014 May 1.
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